Mass Spectrometry Contamination from Tinuvin 770, a Common Additive in Laboratory Plastics
نویسندگان
چکیده
منابع مشابه
Comparative study on cardiotoxic effect of Tinuvin 770: a light stabilizer of medical plastics in rat model.
Tinuvin 770 [bis(2,2,6,6-tetramethyl-4-piperidinyl) sebacate], is a UV light stabilizer plastic additive used worldwide. It is a component of many plastic materials used in medical and food industries. Earlier studies demonstrated its in vitro L-type Ca2+ channel and nicotinic acetylcholine receptor blocking properties. Our previous experiments have proved the toxic effects of Tinuvin 770 on is...
متن کاملA light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker.
A pharmacologically active agent was easily extracted by aqueous or organic solvents from laboratory plastic tubes (Falcon Blue Max) and has been chemically identified as bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate. This compound (approximately 12 micrograms per tube approximately 25 nmol) blocked 1,4-dihydropyridine-sensitive 45Ca2+ uptake into GH3 cells with an IC50 value of 3.6 microM, inh...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Techniques : JBT
سال: 2013
ISSN: 1524-0215,1943-4731
DOI: 10.7171/jbt.13-2402-004